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They've gone from being a somewhat underwhelming and underutilised mechanic in Ixalan to something that borders on being broken thanks to the likes of cards like Korvold, Fae-Cursed King

At first you might want to give it some protection, and the obvious choice for that is indestructible

When you want to use this as a boardwipe, it will also wipe out your own creatures (unless Inspirit, Flagship Vessel is fully crewed), and for that, there are better options

Karn Liberated Karn is not great discard at all

Personally, while I wish this wasnt something that affects serialized cards, that aspect is a) unavoidable, and b) part of the high risk of playing Flip It