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Posthumadeboer J
4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy}methyl)-3
N=C1C=CN2C3OC(CO)C(O)C3OC2=N1
contributes substantially to binding of the protonated CCR2 antagonist 4
A large apparent volume of distribution (138
CCR2 antagonist 4 Catalog No.:M24015-C Posthumadeboer JCCR2 antagonist 4 (Teijin compound 1) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP 1 induced chemotaxis with an IC50 of 24 nM. Product information CAS Number: 226226 39 7 Molecular Weight: 439. 86 Formula: C21H21ClF3N3O2 Chemical Name: N [(3R) 1 [(4 chlorophenyl)methyl]pyrrolidin 3 yl] 2 {[3 (trifluoromethyl)phenyl]formamido}acetamide Smiles:
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