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708±83 mm3
2ClH/c1-25-11-13-26(14-12-25)23(27)16-24-22-15-21(22)19-7-9-20(10-8-19)28-17-18-5-3-2-4-6-18
selective and cell permeable Protein arginine methyltransferase-1 (PRMT1) inhibitor with IC50 of 9
ALK4 (IC50 ~140 nM) and ALK7
Differentiation from protein kinase c isoenzymes
SBI-0206965 - Autophagy Kinase ULK1 Inhibitor. CAS# 1884220-36-3 0129 708±83 mm3SBI 0206965, CAS No. 1884220 36 3, is a potent and selective autophagy Kinase ULK1 Inhibitor. Many tumors become addicted to autophagy for survival, suggesting inhibition of autophagy as a potential broadly applicable cancer therapy. SBI 0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1 mediated phosphorylation events in cells, regulating autophagy and cell survival. SBI 0206965 greatly synergized with mechanistic target
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