Elacridar Hydrochloride ron Pimecrolimus blocks T-lymphocyte activation pathway

Pimecrolimus blocks T-lymphocyte activation pathway by inhibiting calcineurin function

18(6):1965-1971

InChiKey: NDVQUNZCNAMROD-RZUBCFFCSA-N

vinorelbine is more selective against mitotic than axonal microtubules in vitro

CAS Number: 218136-59-5

Elacridar Hydrochloride ron Pimecrolimus blocks T-lymphocyte activation pathwayElacridar, also known as GF120918A, is a P glycoprotein (P gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. In vitro, GF120918A demonstrated high plasma protein binding across species, although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse, rat, and dog