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Currently it is in Phase I clinical trials for advanced head and neck
8 nM) very similar to that of Chrysamine-G
In mice bearing Colo-205 colon carcinoma xenografts (p16 deleted)
InChi: InChI=1S/C7H5N5S2/c8-2-13-4-1-5(14-3-9)7(11)12-6(4)10/h1H
was previously characterized as a RAD51-Stimulatory compound and now found to be an HDR enhancer to enhance CRISPR/Cas9- and TALEN-mediated knock-in efficiency
COMPOUND 401 - CAS# 168425-64-7 033 Currently it is in PhaseCompound 401, CAS No. 168425 64 7, is a potent and selective inhibitor of DNA dependent protein kinase (DNA PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0. 28 and 5. 3 M respectively). Product information CAS Number: 168425 64 7 Molecular Weight: 281. 31 Formula: C16H15N3O2 Synonym: Compound 401 Compound 401 Compound401 Chemical Name: 2 (4 Morpholinyl) 4H pyrimido[2,1 a]isoquinolin 4 one Smiles: O=C1C=C(N=C2C3=CC=CC=C3C=CN21)N1CCOCC1
US$ 160.00
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US$ 938.50
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