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Formula: C16H15N3O2
CAS Number: 1012054-59-9
Nakamura S
double-blind
780 and 1940 nM for ROCK1
OTS-964 hydrochloride - CAS# 1338545-07-5 054 Formula: C16H15N3O2OTS 964 hydrochloride, CAS No. 1338545 07 5, hydrochloride is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), this inhibitor causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. Although administration
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