Doxazosin rasugrel (Maleic acid) 1'-cyclohexan]-2'-ene-3

1'-cyclohexan]-2'-ene-3

and 10 mg/kg) has 27%

Solubility: DMSO: 100 mg/mL(134

Smiles: CC1=CN([C@H]2C=C[C@@H](CO)O2)C(=O)NC1=O

Exposures (AUC) increases in a less than dose-proportional manner from 23 μM•h at 5 mg/kg to 362 μM•h at 500 mg/kg

Doxazosin rasugrel (Maleic acid) 1'-cyclohexan]-2'-ene-3Doxazosin is an 1 adrenergic receptor blocker that inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the 1 receptors on the membrane of vascular smooth muscle cells. Blockages of the alpha 1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity. This agent also shows high affinity to alpha 1c adrenoceptor, the predominant functional type in