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a novel CXCR4 receptor antagonist
It possesses a unique pattern of pleiotropic effects on
CAS Number: 1184991-14-7
Chemical Name: tert-butyl N-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethyl)carbamate
InChi: InChI=1S/C5H8O4/c1-2-3(4(6)7)5(8)9/h3H
MIPS-521 Catalog No.:M33388-100 a novel CXCR4 receptor antagonistMIPS 521 is a positive allosteric modulator of the A1R, exhibits analgesic efficacy in rats in vivo through modulation of the increased levels of endogenous adenosine that occur in the spinal cord of rats with neuropathic pain. We also report the structure of the A1R co bound to adenosine, MIPS521 and a Gi2 heterotrimer, revealing an extrahelical lipid detergent facing allosteric binding pocket that involves transmembrane helixes 1, 6 and 7. Molecular
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