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It can inhibit ULK in vitro and block autophagy in cells
6-dimorpholino-N-(4-nitrophenyl)-1
Frederick R
Sivanathan S
It has no activity against CARM1 and Set7/9 methyltransferases
UNC0638 - G9a HMTase Inhibitor. CAS# 1255580-76-7 0332 It can inhibit ULK inUNC0638, CAS No. 1255580 76 7, is a potent, selective and cell permeable G9a and GLP inhibitor, with a toxicity function ratio of >100, compared to <6 for BIX01294. UNC0638 inhibits G9a HMTase with an IC50 ~15 nM and GLP, a closely related H3K9 HMTase, with an IC50~19 nM, but is more than 10, 000 fold selective over other epigenetic targets. G9a (EHMT2) and GLP (EHMT1) catalyze the mono and dimethylation of lysine 9 of histone 3 (H3K9) and other non
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