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PubMed Central PMCID: PMC4109838
8(8):1698-703
a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo
InChiKey: YTZALCGQUPRCGW-MXVXOLGGSA-N
UNC2327 was used at 5-10 µM final concentration in various in vitro assays
Valrubicin - CAS# 56124-62-0 123 PubMed Central PMCID: PMC4109838Valrubicin, CAS No. 56124 62 0, is a semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the