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Panarese JD
PubMed PMID: 15290686
11-pentaene-6-carboxamide
Molecular Weight: 1033
Anticancer Agents Med Chem
NRX-252114 ncristine Panarese JDNRX 252114 is a potent enhancer of the interaction between catenin, and its cognate E3 ligase, SCF TrCP. NRX 252114 enhances the binding of pSer33 S37A catenin peptide for TrCP with an EC50 of 6. 5 nM and a Kd of 0. 4 nM. NRX 252114 induces mutant catenin degradation. Product information Molecular Weight: 510. 32 Formula: C22H12Cl2F3N3O2S Chemical Name: 2 {4 [(2,6 dichlorophenyl)sulfanyl] 2 oxo 6 (trifluoromethyl) 1,2 dihydropyridine 3 carbonyl} 2,3
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