LIN28 inhibitor LI71 - CAS# 1357248-83-9 Catalog No.:M7073-2 Irreversible inhibition of cytosolic thioredoxin

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy

(2009) Nature Method 6

(1985) Proc Natl Acad Sci USA

Epub 2013 Oct 23

Smiles: CC1=NC(=CS1)/C=C(\C)/[C@@H]1C[C@@H]2O[C@@H]2CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1

LIN28 inhibitor LI71 - CAS# 1357248-83-9 Catalog No.:M7073-2 Irreversible inhibition of cytosolic thioredoxinLIN28 inhibitor LI71, CAS No. 1357248 83 9, is a potent, cell permeable inhibitor of LIN28 that abolishes LIN28 mediated oligouridylation. LIN28 inhibitor LI71 binds the cold shock domain to suppress LIN28's activity against let 7 in leukemia cells and embryonic stem cells. . Product information CAS Number: 1357248 83 9 Molecular Weight: 335. 40 Formula: C21H21NO3 Synonym: LIN28 inhibitor LI71 I71 L I71 Chemical Name: 4 ((3aS,4R,9bR) 6 ethoxy