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PubMed Central PMCID: PMC4082357
TOFA is found to be cytotoxic to COC1 and COC1/DDP cells with IC50 values of ~26
50(2):355-67
Smiles: O=C1N=C(NS(=O)(=O)C2=CC=CC3=CC=CC=C32)S/C/1=C\C1C=CC(Br)=CC=1
CAS Number: 20187-55-7
Fezolinetant HCl Size:10 mg solid PubMed Central PMCID: PMC4082357Fezolinetant, also known as ESN 364, is Neurokinin 3 (NK 3) receptor antagonist which has been optimized for use in womens health, and is being developed for sex hormone related disorders such as endometriosis, polycystic ovarian syndrome and uterine fibroids. Fexolinetant allows modulation of the hypothalamic pituitary gonadal axis with a selective action on hormones relevant to disease. The agent is expected to have greater tolerability than