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potent NS3/4A protease inhibitor for the oral treatment of HCV infection
7 μM and >10 μM
83280-65-3
is the potent and selective small molecular inhibitor of KRAS-PDEδ interaction
Pyridostatin TFA induces the formation of DNA DSBs
PFI-2 Hydrochloride 60099 potent NS3/4A protease inhibitor forPFI 2 is a potent inhibitor of SETD7 with IC50 2 nM and 1000 fold selectivity over other methyltransferases and other non epigenetic targets. PFI 2 has been shown to bind to SETD7 by ITC (Kd=18nM) and biotinylated PFI 2 interacts with SETD7 in pull down studies. Its enantiomer (S) PFI 2 is 500 fold less active making it an excellent negative control. Treatment of low density MEFs with (R) PFI 2 resulted in higher nuclear YAP levels indicating an