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CC-115 is evaluated using both once (qd) and twice (bid) daily dosing schedules
Formula: C8H10N2O4S
Cancer Biol Ther
a cathepsin K inhibitor
2-H)ethyl](2-chloroethyl)amino}-1-methyl-1H-1
LEE011 succinate hydrate(1:1:x) Catalog No.:M9046-2 CC-115 is evaluated using bothLEE011 succinate hydrate is an orally available cyclin dependent kinase (CDK) inhibitor targeting cyclin D1 CDK4 and cyclin D3 CDK6 cell cycle pathway, with potential antineoplastic activity. CDK4 6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK mediated G1 S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing
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