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Formulation is 1% (v/v) solution of ethanol/solutol/water (10/40/50%)
inhibits Nedd4
promoted cytokine independence and blocks differentiation in hematopoietic cells
correlates with CK2α mRNA and protein levels but not the CK2α' catalytic subunit
It has been shown to promote goblet cell differentiation in mouse intestine
PBIT - JARID1 Histone Demethylases Inhibitor. CAS# 2514-30-9 Catalog No.:M60170-10S Formulation is 1% (v/v) solutionPBIT, CAS No. 2514 30 9, is a potent, specific, reversible and cell permeable inhibitor of Jumonji AT Rich Interactive Domain 1 (JARID1) histone demethylases. It inhibits JARID1B (also known as KDM5B or PLU1) with an IC of ~3 M in vitro. It also inhibits the activity of other related histone demethylases JARID1A, JARID1C, and JMJD2E with IC50 ~6, 4. 9, and 28 M respectively. PBIT does not affect the activity of unrelated UTX and JMJD3 H3K27me3
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