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6S)-29-oxa-1
Solubility: DMSO: 100 mg/mL(147
Chemical Name: 6-[2-chloro-4-(1
30(35)36)25-17-15-24(16-18-25)29(34)14-9-21-33-22-19-28(20-23-33)32(37
4-dimethoxypyridin-2-yl)methanesulfinyl]-1H-1
AST 487 - CAS# 630124-46-8 Size:Solid 2 mg 6S)-29-oxa-1AST487, also known as NVP AST487, is a RET kinase inhibitor FLT3 inhibitor. The RET kinase has emerged as a promising target for the therapy of medullary thyroid cancers (MTC) and of a subset of papillary thyroid cancers. NVP AST487 has an IC(50) of 0. 88 mumol L on RET kinase, inhibits RET autophosphorylation and activation of downstream effectors, and potently inhibited the growth of human thyroid cancer cell lines with activating mutations of RET
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