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8(4):467-479
30 min prior to UVB irradiation for 30 weeks) suppresses development of squamous cell carcinoma in SKH-1 hairless mice
It facilitates extinction and prevents reinstatement of cocaine-conditioned place preference
GKT137831 reduced the hypoxia-induced increase in ROS levels and protein expression of various inflammatory mediators
PubMed PMID: 26259519
Ispinesib (SB-715992) st N-oxide 8(4):467-479Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be
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