FPS-ZM1 - CAS# 945714-67-0 0078 and Ca(2+) mobilization assays

and Ca(2+) mobilization assays

SK-MEL-28 and A375 (IC50 from 30-250 nM)

InChiKey: TXJZRSRTYPUYRW-NQIIRXRSSA-N

both of which are critical for glutamate-mediated signal transduction mechanisms

5% methylcellulose

FPS-ZM1 - CAS# 945714-67-0 0078 and Ca(2+) mobilization assaysFPS ZM1, CAS No. 945714 67 0, is a high affinity RAGE specific blocker that inhibits amyloid binding to RAGE, neurological damage and inflammation in the APP(sw 0) transgenic mouse model of AD. FPS ZM1 is not toxic to mice and can easily cross the blood brain barrier. AGEs administration induced an regulation of Abeta production, inflammation, and oxidative stress, and an increased escape latency of rats in the Morris water maze test, all of these are