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Guanidine hydrochloride is the compound derived from G
Chemical Name: N-(9-{[4-(dimethylamino)phenyl]amino}-6-[3-(pyrrolidin-1-yl)propanamido]acridin-3-yl)-3-(pyrrolidin-1-yl)propanamide trihydrochloride
even in dormant or nonreplicating mycobacteria
CN1CCN(CCCN2C3=CC=CC=C3SC3=CC=C(C=C23)C(F)(F)F)CC1
InChiKey: QBGSVDJLQQXEGG-UHFFFAOYSA-N
Luotonin A NB 142-70 Guanidine hydrochloride is the compoundIC50: 1. 8 g mL for P 388 cell line Luotonin A binds to and stabilizes the topoisomerase I DNA binary complex. Topoisomerase DNA complexes have been reported as the primary target of several important antitumor agents. These agents have been shown to be able to increase the number of topoisomerase associated DNA strand breaks in cells, by stabilizing the covalent enzyme DNA complex and therefore diminishing the resealing of the DNA phosphodiester
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