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It has at least 60-fold selectivity as an inhibitor of the KDM2/7 subfamily over the other demethylase subfamily members such as KDM3A
Chemical Name: (Z)-3-(acetoxyimino)-5-chloro-1-(2
Osthole (Osthol) is a natural antihistamine alternative
is a potent and selective antagonist of the G protein-coupled receptor identified as EBI2 (GPR183) (IC50 values are 11 and 15 nM for human and mouse EBI2 receptors
Solubility: DMSO: 71 mg/mL(198
Roscovitine (Seliciclib) D318088 It has at least 60-foldSeliciclib, also known as roscovitine and CYC202, is a n orally bioavailable, small molecule cyclin dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2 E, CDK2 A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK mediated phosphorylation of the carboxy terminal domain
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