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Ritanserin (R 55667) is a highly potent
DZ-2002 is a potent reversible inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH)
increases p-EGFR in both BRAF V600E mutant and BRAF wild type cells
TP-064 is a potent and selective proteinarginine methyltransferase 4 (PRMT4
Se-Methylseleno-L-cysteine
CDK12-IN-2 andicarboxylic acid Ritanserin (R 55667) is aCDK12 IN 2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12 IN 2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12 IN 2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12 IN 2 inhibits the phosphorylation of Ser2 in the C terminal domain of RNA polymerase II. CDK12 IN 2 can be used an excellent chemical probe for functional studies
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