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SAR-100842 13341 EMT inhibitor-1 induces GSK3-β–mediated degradation

SKU: 92554611658

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Description

EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ

Epub 2015 Sep 16

InChiKey: HBSUHPVFGADBOQ-WQVNFKRKSA-N

Molecular Weight: 197

Xiaoqin Tong

SAR-100842 13341 EMT inhibitor-1 induces GSK3-β–mediated degradationSAR 100842 is a lysophaphatidic acid 1 (LPA1 Edg 2) receptor inhibitor. SAR 100842 (Compound Example 14) is an Edg 2 receptor inhibitor extracted from patent WO2009135590A1, has an IC50 of <0. 1 M. SAR 100842 (SAR100842) is a lysophaphatidic acid receptor 1 (LPA1) inhibitor, which can be used for the treatment of systemic sclerosis and related fibrotic diseases. In LPAR1 based in vitro inhibition of LPA stimulated Ca2+ flux in a cell based assay, SAR

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