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48(25):8045-54
BMS 201038-01
Quizartinib (AC220) is a novel compound expressly optimized as a FLT3 inhibitor for the treatment of acute myeloid leukemia (AML)
Smiles: NC(=O)OCC(COC(N)=O)C1C=CC=CC=1
InChiKey: YOZBGTLTNGAVFU-UHFFFAOYSA-N
FG-4592 (Roxadustat) - HIF Prolyl-Hydroxylases Inhibitor. CAS# 808118-40-3 Catalog No.:M60263-10S 48(25):8045-54FG 4592 (Roxadustat), CAS No. 808118 40 3, is a potent, selective and bioavailable inhibitor of hypoxia inducible factor prolyl hydroxylase. It is an analog of 2 oxoglutarate (2 OG) to inhibit HIF PH and prevent HIF turnover. While little has been published regarding the actions of this compound, similar HIF PH inhibitors suppress HIF degradation and in this way induce erythropoietin expression, promoting erythropoiesis or preventing anemia in vivo.
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