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Abiraterone acetate (pro-drug) was dosed to mice and rats at 50 mg/kg orally once per day
PubMed Central PMCID: PMC3949762
PubMed PMID: 27709282
albeit with less potency
demonstrates near-complete inhibition of KRAS signaling in tumor tissue
4,4,4-Trifluoro-1-(thiophen-2-yl)-2-(2-(m-tolyl)hydrazono)butane-1,3-dione eceptor Agonist Abiraterone acetate (pro-drug) was dosedGR148672X is a triacyglycerol hydrolase (TGH) inhibitor with an IC50 of 4 nM extracted from patent WO 2001016358 A2. Product information CAS Number: 263890 70 6 Molecular Weight: 340. 32 Formula: C15H11F3N2O2S Chemical Name: (2Z) 4,4,4 trifluoro 2 [2 (3 methylphenyl)hydrazin 1 ylidene] 1 (thiophen 2 yl)butane 1,3 dione Smiles: CC1=CC(=CC=C1)N N=C(\C(=O)C1=CC=CS1) C(=O)C(F)(F)F InChiKey: YNUQHMHMYSUKFL UDWIEESQSA N InChi: InChI=1S C15H11F3N2O2S c1 9 4
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