AI-10-49 - CAS# 1256094-72-0 60268 and HER2 inhibitor for the

and HER2 inhibitor for the treatment of cancer

2017 Jan 1

Remodelin was used at 1-10 µM in vitro and cellular assays

Two small molecule agonists of glucagon-like peptide-1 receptor modulate the receptor activation response differently

CAS Number: 5428-80-8

AI-10-49 - CAS# 1256094-72-0 60268 and HER2 inhibitor for theAI 10 49, CAS No. 1256094 72 0, is an inhibitor that binds the transcription factor fusion CBF SMMHC. AI 10 49, that selectively binds to CBF SMMHC and disrupts its binding to RUNX1. AI 10 49 restores RUNX1 transcriptional activity, displays favorable pharmacokinetics, and delays leukemia progression in mice. Treatment of primary inv(16) AML patient blasts with AI 10 49 triggers selective cell death. These data suggest that direct inhibition of the