Asenapine Hydrochloride - CAS# 1412458-61-7 uorowillardiine hydrochloride InChiKey: KTUFKADDDORSSI-UHFFFAOYSA-N

InChiKey: KTUFKADDDORSSI-UHFFFAOYSA-N

Chemical Name: N-(5-{4-[(6-cyanopyridin-3-yl)methoxy]phenyl}-[1

PubMed PMID: 31757294

Smiles: CN(C)CCN(C)C1=CC(OC)=C(C=C1NC(=O)C=C)NC1=NC(C2=CNC3=CC=CC=C32)=C(Cl)C=N1

is an orally bioavailable inhibitor of monopolar spindle 1 (MPS1/TTK) kinase (IC50 = 1

Asenapine Hydrochloride - CAS# 1412458-61-7 uorowillardiine hydrochloride InChiKey: KTUFKADDDORSSI-UHFFFAOYSA-NAsenapine, also known as Org 5222 and HSDB 8061, shows high affinity (pKi) for numerous receptors, including the serotonin 5 HT1A (8. 6), 5 HT1B (8. 4), 5 HT2A (10. 2), 5 HT2B (9. 8), 5 HT2C (10. 5), 5 HT5A (8. 8), 5 HT6 (9. 5), and 5 HT7 (9. 9) receptors, the adrenergic 1 (8. 9), 2A (8. 9), 2B (9. 5), and 2C (8. 9) receptors, the dopamine D1 (8. 9), D2 (8. 9), D3 (9. 4), and D4 (9. 0) receptors, and the histamine H1 (9. 0) and H2 (8. 2) receptors.