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CB-1158 in combination with PD-L1 blockade or gemcitabine inhibits tumor growth in mice bearing CT26 cancer cells
PubMed PMID: 11595239
DWN63831 was first reported in patent WO 2020024017
but the majority of these lesions have disappeared at week 48
Ilexhainanoside D is the main triterpenoid saponin extracted from Ilex hainanensis Merr
MCX 28 ylcholine chloride calcium salt tetrahydrate CB-1158 in combination with PD-L1MCX 28, a triple PI3K mTOR PIM inhibitor, displays low nanomolar activity. Product information CAS Number: 1414453 58 9 Molecular Weight: 549. 64 Formula: C25H19N5O4S3 Chemical Name: 25 methoxy 31 methyl 3, 22, 30 trithia 6, 8, 15, 23, 26 pentaazahexacyclo[22. 3. 1. 1, . 1, . 1, . 0, ]hentriaconta 1(27), 2(31), 4, 6, 8, 10, 12, 17(29), 18, 20, 24(28), 25 dodecaene 16 Smiles: CC1C2=NC=NC3C4=CC=C(CNC(=O)C5=CC(=CC=C5)S(=O)(=O)NC5=CC(=CN=C5OC)C=1SC=32)S4