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InChiKey: ROYXIPOUVGDTAO-UHFFFAOYSA-N
injection of S3I-201 (NSC-74859) or vehicle every 2 or every 3 days for 2 weeks
Hedgehog acyltransferase as a target in pancreatic ductal adenocarcinoma
000-fold selective for 20 other human methyltransferases
Formula: C20H22N2O
DASA-58 (ML203) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1203494-49-8 size:2 mg solid InChiKey: ROYXIPOUVGDTAO-UHFFFAOYSA-NDASA 58 (ML203), CAS No. 1203494 49 8, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~38 nM. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. DASA 58 inhibits LPS induced Hif 1 and IL 1, as well as the expression of a range of other Hif 1 dependent
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