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including C32 melanoma
Smiles: CC1(C)O[C@@H](OC2=CC=C3C(OC(=O)C(NC(=O)C4NC=C(C(=O)NC5C(=O)OC6=C(C=CC(O[C@@H]7OC(C)(C)[C@H](OC)[C@@H](OC(=O)C8=CC=C(C)N8)[C@H]7O)=C6C)C=5O)C=4C)=C3O)=C2C)[C@H](O)[C@H](OC(=O)C2=CC=C(C)N2)[C@H]1OC
KUN79359 (14 μM
Boothman DA
77(1):58-69
SKI-178 Size:10mg solid including C32 melanomaSKI 178 is a potent sphingosine kinase 1 (SphK1) and SphK2 inhibitor. SKI 178 is cytotoxic at IC50 concentrations ranging from 1. 8 to 0. 1 M in both drug sensitive and multi drug resistant cancer cell lines (i. e., MTR3, NCI ADR and HL60 VCR cells). SKI 178 induces apoptosis in a CDK1 dependent manner in human acute myeloid leukemia cell lines. Product information CAS Number: 1259484 97 3 Molecular Weight: 394. 42 Formula: C21H22N4O4 Chemical Name: