Febuxostat 5132 possible use for in vivo

possible use for in vivo study (IP dosing 15-50 mg/kg

selective inhibitor of VEGFR-2 tyrosine kinase (IC50 = 0

so it has IC50 >1 µM for inhibiting demthylation of H3K4 in U2OS human osteosarcoma cell line and in human breast adenocarcinoma MCF7 tumor cell proliferation assay

SHEP-1 cells are exposed to varying concentrations of LY-303511 (LY30)

with 32% and 44% inhibition at 5 and 20 mg/kg/day

Febuxostat 5132 possible use for in vivoFebuxostat, also known as Uloric and TMX 67, is a xanthine oxidase inhibitor used to treathyperuricemia and chronic gout. Product information CAS Number: 144060 53 7 Molecular Weight: 316. 37 Formula: C16H16N2O3S Synonym: TEI 6720 TMX 67 Uloric FBX Chemical Name: 2 [3 cyano 4 (2 methylpropoxy)phenyl] 4 methyl 1,3 thiazole 5 carboxylic acid Smiles: CC1N=C(SC=1C(O)=O)C1=CC(C#N)=C(C=C1)OCC(C)C InChiKey: BQSJTQLCZDPROO UHFFFAOYSA N InChi: InChI=1S