Isorhynchophylline Catalog No.:M31156-C 3-d]pyrimidin-7-yl}-5-[(R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl]oxolane-3

3-d]pyrimidin-7-yl}-5-[(R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl]oxolane-3

InChi: InChI=1S/2C7H9ClO6P2S

CG-806 exerts potent picomolar IC50 anti-proliferative activity against human AML cells and against Ba/F3 mouse AML cells with FLT3-ITD mutations (about 50 to 250-fold higher activity compared to quizartinib or gilteritinib)

Chemical Name: 5-(dimethylsulfamoyl)-N-(5-methyl-1

and disrupts c-Met signal transduction pathways

Isorhynchophylline Catalog No.:M31156-C 3-d]pyrimidin-7-yl}-5-[(R)-(4-chloro-3-fluorophenyl)(hydroxy)methyl]oxolane-3Isorhynchophylline (IRN), an alkaloid isolated from Uncaria rhynchophylla, possesses the effects of lowered blood pressure, vasodilatation and protection against ischemia induced neuronal damage. IC50 value: Target: In vitro: Isorhynchophylline concentration dependently inhibited the platelet derived growth factor (PDGF) BB induced proliferation of PASMCs. Fluorescence activated cell sorting analysis showed that isorhynchophylline caused G0 G1 phase