R-GNE-140 - CAS# 2003234-63-5 size:2mg solid is a highly potent and

is a highly potent and selective small molecule that promotes pancreatic β cell proliferation in rodent and human primary islets

is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure

selective and cell permeable BRPF1 bromodomain inhibitor with IC50 ~ 80 nM

4S)-3-ethylidene-4-(2-oxo-2-{[(2R

7(5):531-6

R-GNE-140 - CAS# 2003234-63-5 size:2mg solid is a highly potent andR GNE 140, CAS No. 2003234 63 5, a novel potent lactate dehydrogenase (LDHA) inhibitor with IC50 3nM for LDHA and 5 nM for LDHB. In MIA PaCa 2 human pancreatic cells, LDHA inhibition rapidly affected global metabolism, although cell death only occurred after 2 d of continuous LDHA inhibition. Pancreatic cell lines that utilize oxidative phosphorylation (OXPHOS) rather than glycolysis were inherently resistant to GNE 140, but could be resensitized to