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One positive is that self-mill effects tend to be much cheaper than actual card draw, meaning you can access a larger chunk of your deck earlier in the game

If at least one target is still legal at that time, the spell resolves, but an illegal target can't perform any actions or have any actions performed on it

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If you do have a deck that can easily hold back five mana each turn, then chances are you're already in a winning position and are much better off dumping all that mana into a big X spell like Genesis Wave or some haymaker like Expropriate

Played early game it can also be used as effective hand disruption, and just knowing it is in a deck can keep opponents from committing to the board