Smiles: O=C1C=CC2NC=CC3C=2N1C1=CC=CC(=O)C=31
with an IC50 in the micromolar range
single oral administration of ASP9521 suppressed AD-induced intratumoural testosterone production in a dose-dependent manner
Pregnenolone and progesterone are avidly metabolized to 5α-pregnan-3β
InChi: InChI=1S/C13H20N2O4/c1-14-4-6-15(7-5-14)12(16)10-8-2-3-9(19-8)11(10)13(17)18/h8-11H
Lei-Dab7 TFA ximab Smiles: O=C1C=CC2NC=CC3C=2N1C1=CC=CC(=O)C=31Lei Dab7 TFA is a high affinity, selective KCa2. 2 (SK2) channel blocker (Kd=3. 8 nM). Lei Dab7 TFA exhibits >200 fold selectivity for KCa2. 2 over KCa2. 1, KCa2. 3, KCa3. 1, Kv and Kir2. 1. Lei Dab7 TFA increases theta burst responses and increases LTP in rat hippocampal slices in vitro. Product information Molecular Weight: 3508. 10 Formula: C143H239F3N46O41S6 Chemical Name: (3S, 6S, 9S, 12R, 15S, 18S, 21S, 27S, 30S, 36S, 39R, 42S, 48S) 48 (((S) 6