YS-121 AC for CDK6 Smiles: OCC1=C(O)C2=C(C=C1O)C(=O)C1=CC=CC=C1C2=O

Smiles: OCC1=C(O)C2=C(C=C1O)C(=O)C1=CC=CC=C1C2=O

27)24-7-5-14(6-8-24)19(25)23-12-13-1-3-17(22)4-2-13/h1-4

1-15H3/t22-

CAS Number: 59870-65-4

Linoleyl alcohol

YS-121 AC for CDK6 Smiles: OCC1=C(O)C2=C(C=C1O)C(=O)C1=CC=CC=C1C2=OYS 121 is a dual inhibitor of Microsomal prostaglandin E2 synthase 1 (mPGES 1) . Cyclooxygenases (COX 1 and COX 2) have been involved in catalyzing the formation of prostaglandins and related eicosanoids and play an essential role in the pathogenesis of breast cancer. Actions of COX 2 are mediated by prostaglandin E2 (PGE2). Microsomal PGES 1 (mPGES 1), the inducible form of PGES, has a marked affinity for coupling with COX 2. Expression of mPGES 1