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22-hexaoxa-12
the excreted radioactivity up to 168 h is 11
which is a positive effector of cell growth and survival
12H2/b25-19+
2020 Jun 2
PROTAC BRD4 Degrader-11 5-2 22-hexaoxa-12PROTAC BRD4 Degrader 11 (compound 9a) is a PROTAC connected by ligands for von Hippel Lindau and BRD4. PROTAC BRD4 Degrader 11 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0. 23 nM and 0. 38 nM, respectively. Product information Molecular Weight: 1292. 56 Formula: C61H75F2N9O12S4 Chemical Name: (2S,4R) 1 [(2S) 2 (11 {[8 (3,5 difluoropyridin 2 yl) 4 (methanesulfonylmethyl) 15