IU1 - Proteasome USP14 Inhibitor. CAS# 314245-33-5 size:10mg solid 31)32/h9-14

31)32/h9-14

It was also used in an assay where primary bovine articular chondrocytes and cartilage explants were grown in the presence of TNF-a and oncostatin M to mimic cytokine-induced damage during OA pathogenesis

and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)

4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide

Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies

IU1 - Proteasome USP14 Inhibitor. CAS# 314245-33-5 size:10mg solid 31)32/h9-14IU1, CAS No. 314245 33 5, is a cell permeable, reversible and selective inhibitor of human USP14 with an IC50 of 4. 7 M. It selectively stimulates ubiquitin dependent protein degradation in vitro at 34 M and in MEF cells at 50 M. At 75 M, IU1 reduces accumulation of oxidized proteins in HEK293 cells, alleviating cytotoxicity induced by oxidative stress. Usp14 inhibition accelerated the degradation of oxidized proteins and enhanced resistance to