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Phosphorylation of RPS6KB1 and EIF4EBP1 is significantly increased by 3BDO with vector alone but suppressed with FKBP1A overexpression
Thalidomide-O-amido-PEG-C2-NH2 hydrochloride
InChiKey: SSISHJJTAXXQAX-ZETCQYMHSA-N
21-54-44)28(47)18-42(41
34R)-18-hydroxy-34-[(1S)-1-hydroxyethyl]-23
ATR inhibitor 2 oxamide Tromethamine Phosphorylation of RPS6KB1 and EIF4EBP1ATR inhibitor 2 is an ATP competitive, orally active, and selective ATR inhibitor, with a Ki of <150 pM. ATR inhibitor 2 potently inhibits ATR driven phosphorylated checkpoint kinase 1 (Chk1) phosphorylation with an IC50 of 8 nM. Antitumor activity. Product information CAS Number: 1613191 99 3 Molecular Weight: 541. 55 Formula: C25H29F2N9O3 Chemical Name: 2 amino 6 fluoro N (5 fluoro 4 {4 [4 (oxetan 3 yl)piperazine 1 carbonyl]piperidin 1 yl}pyridin 3