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000 μg/L)
is a novel PDK1 (phosphoinositide-dependent protein kinase 1) activator (Kd = 10
is a potent and selective small molecule to activate both Oct4 and Nanog promoter-driven luciferase reporter genes
Dermatol Ther
so it has IC50 >1 µM for inhibiting demthylation of H3K4 in U2OS human osteosarcoma cell line and in human breast adenocarcinoma MCF7 tumor cell proliferation assay
CPI-444 - CAS# 1202402-40-1 0101 000 μg/L)CPI 444, CAS No. 1202402 40 1, is an orally administered antagonist of the adenosine A2A receptor. Upon oral administration, CPI 444 binds to adenosine A2A receptors expressed on the surface of immune cells, including T lymphocytes, natural killer (NK) cells, macrophages and dendritic cells (DCs). This prevents tumor released adenosine from interacting with the A2A receptors on these key immune surveillance cells, thereby abrogating adenosine induced
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