Aβ42-IN-1 free base 13437 is a 2-methoxyestradiol analogue with

is a 2-methoxyestradiol analogue with antiproliferative and antiangiogenic activity

8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1

CTEP allows the exploration of the full therapeutic potential of mGlu5 inhibitors for indications requiring chronic receptor inhibition

61(12):5235-5244

PubMed PMID: 28391375

Aβ42-IN-1 free base 13437 is a 2-methoxyestradiol analogue withA42 IN 1 free base (compound 1v) is an orally active, high brain exposure secretase modulator. A42 IN 1 free base potently reduces A42 levels with an IC50 value of 0. 091 M, and significantly reduces brain A42 levels in mice. A42 IN 1 free base is a promising compound for the treatment of Alzheimers disease. Product information CAS Number: 2434633 17 5 Molecular Weight: 462. 54 Formula: C29H26N4O2 Chemical Name: 5 [8 ({[1,1' biphenyl] 4 yl}methoxy) 2