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After oral and intravenous administration
37(6):e381-3
5 log cell kill (LCK)
39(12):6895-6901
PNU-74654 binds to β-catenin with a KD of 450 nM
MC-GGFG-DX8951 K4028 After oral and intravenous administrationMC GGFG DX8951 is a drug linker conjugate for ADC with antitumor activity by using DX8951 (a DNA topoisomerase I inhibitor), linked via the protease cleavable MC GGFG linker. Product information CAS Number: 1600418 29 8 Molecular Weight: 946. 97 Formula: C49H51FN8O11 Chemical Name: 6 (2,5 dioxo 2,5 dihydro 1H pyrrol 1 yl) N {[({[(1S) 1 [({[(10S,23S) 10 ethyl 18 fluoro 10 hydroxy 19 methyl 5,9 dioxo 8 oxa 4,15 diazahexacyclo[14. 7. 1. 0,. 0,. 0,.