P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid Chemical Name: 8-(6-methoxypyridin-3-yl)-3-methyl-1-(4-(3-(trifluoromethyl)piperazin-1-yl)phenyl)-1H-imidazo[4

Chemical Name: 8-(6-methoxypyridin-3-yl)-3-methyl-1-(4-(3-(trifluoromethyl)piperazin-1-yl)phenyl)-1H-imidazo[4

Formula: C24H26N6O3

is a highly specific inhibitor of Cdk4 (IC50=11 nM) and Cdk6 (IC50=16 nM)

and represses tumor growth

ultimately leading to apoptosis

P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid Chemical Name: 8-(6-methoxypyridin-3-yl)-3-methyl-1-(4-(3-(trifluoromethyl)piperazin-1-yl)phenyl)-1H-imidazo[4P5091 (P005091), CAS No. 882257 11 6, is a novel potent and selective inhibitor of ubiquitin specific protease 7 (USP7) with an IC50 ~4. 2 M. It does not inhibit other DUBs or other families of cysteine proteases tested (EC50 > 100 mM). It induces apoptosis in MM cells resistant to conventional and bortezomib therapies. Biochemical and genetic studies showed that blockade of HDM2 and p21 abrogated P5091 induced cytotoxicity. In animal tumor model