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13(17)-hexaene-5-carboxamide
Smiles: CC1C=C(C(=CC=1C(=O)NC(N)=N)S(C)(=O)=O)N1C=CC=C1
Formula: C24H25Cl2N5O3
A single 10 mg/kg oral dose of Altiratinib exhibits complete inhibition of MET phosphorylation through 12 hours and 73% inhibition at 24 hours postdose
Konstorum A
ARL 17477 dihydrochloride B2 Ligand 13(17)-hexaene-5-carboxamideARL 17477 dihydrochloride is a selective and potent neuronal nitrogen oxide synthase (nNOS) inhibitor with IC50 values of 1 and 17M for nNOS and endothelial NOS, respectively . Neuronal NOS (nNOS) plays an important role in the development of ischaemic brain necrosis while endothelial NOS (eNOS) protects brain tissue through increasing ischaemic regional cerebral blood flow . In rats after transient MCA occlusion, ARL 17477 (1mg kg, 3mg kg and 10mg
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