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Purvalanol A - CAS# 212844-53-6 181 Smiles: O=S(=O)(CC1CS1)C1C=CC(=CC=1)OC1C=CC=CC=1

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Description

Smiles: O=S(=O)(CC1CS1)C1C=CC(=CC=1)OC1C=CC=CC=1

Pressler ML

VLX600 shows enhanced cytotoxic activity under conditions of nutrient starvation

S3I-201 treatment of somatotroph tumor xenografts (n=15) significantly attenuated tumor growth for the duration of the experiment

Epub 2012 Sep 2

Purvalanol A - CAS# 212844-53-6 181 Smiles: O=S(=O)(CC1CS1)C1C=CC(=CC=1)OC1C=CC=CC=1Purvalanol A, CAS No. 212844 53 6, is a potent CDK inhibitor, which effectively suppresses Src mediated transformation by inhibiting both CDKs and c Src. indicating that the activation of CDKs contributes to the c Src transformation. Purvalanol A suppressed the c Src activity as effectively as the Src selective inhibitor PP2, and that it reverted the transformed morphology to a nearly normal shape with less cytotoxicity than PP2. Purvalanol A induced

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