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E6446 (20 mg/kg
Of the 24 cell lines
30 minutes) causes sustained decrease in the basal pHi in isolated rat ventricular myocytes
098 μg/mL
CHMFL-ABL-053 did not exhibit apparent potency against c-KIT kinase (IC50: over 10000 nM)
22(R)-hydroxy Cholesterol Catalog No.:M22746-C E6446 (20 mg/kgEC50: 325 nM 22(R) hydroxy cholesterol is an endogenous agonist for liver X receptors (LXRs). The liver X receptors, LXRR and LXR, together with the farnesoid X receptor, FXR, form a subfamily of these orphan receptors. Recently, it has been reported that LXR and FXR are hormone receptors for oxysterols and bile acids, respectively. In vitro: Previous study found that 22(R) hydroxycholesterol was only found in the adrenals as an intermediate in