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Chemical Name: 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2
InChiKey: MMMNTDFSPSQXJP-UHFFFAOYSA-N
Molecular Weight: 1134
[Epub ahead of print] PubMed PMID: 20525876
3-oxazol-5-one
R428 - CAS# 1037624-75-1 R-623 Chemical Name: 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2Bemcentinib, also known as BGB 324 or R428, is a selective small molecule inhibitor of Axl kinase, which showed activity to blocks tumor spread and prolongs survival in models of metastatic breast cancer. The receptor tyrosine kinase Axl may play an important role in cancer progression, invasion, metastasis, drug resistance, and patient mortality. R428 inhibits Axl with low nanomolar activity and blocked Axl dependent events, including Akt
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