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WIN-552122
Smiles: C[C@@H]1COCCN1C1=CC(=NC(=N1)C1C=CC=C2NC=CC=12)C1(CC1)S(C)(=O)=O
CPI203 could be dosed to the mice by oral administration at 5 mg/kg twice per day for 7 days
pii: S0006-2952(16)30380-X
Jaudszus A
ABC294640 - CAS# 915385-81-8 Catalog No.:M6465-10 WIN-552122ABC294640, also known as Opaganib, CAS No. 915385 81 8, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase 2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro apoptotic amino alcohol sphingosine to sphingosine 1 phosphate (S1P), the lipid mediator that is pro survival and critical for