D-Sphingosine - CAS# 123-78-4 Catalog No.:M6801-10 9-tetrahydro-1H-pyrido[3

9-tetrahydro-1H-pyrido[3

is potent ROCK inhibitor

4]oxazepin-4(5H)-yl)propan-1-one

InChi: InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H

(1992) Proc Natl Acad Sci USA

D-Sphingosine - CAS# 123-78-4 Catalog No.:M6801-10 9-tetrahydro-1H-pyrido[3D Sphingosine, CAS No. 123 78 4, is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase. D sphingosine, a lipid possessing the same hydrophobic base as ceramide but without a carbohydrate residue, efficiently blocked this glycolipid antigen presentation both in vitro and in spinal cords of EAE mice, and significantly decreased IL 17 and ameliorated the pathological symptoms.