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J Pharm Belg
Smiles: O=C(NCC1(CCOCC1)C1=NC(=CS1)C1C=CC=CC=1)C1C=C(C=CC=1)C1N=C(ON=1)C(F)(F)F
425(6960):780-2
Smiles: COC(=O)CCC1C2=CC3=NC(=CC4NC(C=C5N=C(C=C(N2)C=1C)[C@]1(C)[C@@H](C(=CC=C15)C(=O)OC)C(=O)OC)=C(C)C=4C=C)C(C)=C3CCC(O)=O
Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors
CUDC-101 - HDAC/EGFR/HER2 Inhibitor. CAS# 1012054-59-9 60129 J Pharm BelgCUDC 101, CAS No. 1012054 59 9, is a potent multi target inhibitor targeting HDAC, EGFR and HER2 with IC50 of 4. 4 nM, 2. 4 nM, and 15. 7 nM, respectively. It is specific for class I and class II HDACs, not for class III Sir type HDACs, and has > 50 fold selectivity against other protein kinases. CUDC 101 displays broad antiproliferative activity in many human cancer cell types with IC50 of 0. 04 0. 80 M, exhibiting a higher potency than erlotinib,
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